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Niraparib (R-enantiomer)
🥰Excellent
Catalog No. T12064Cas No. 1038915-58-0
Alias Niraparib R-enantiomer, MK 4827 (R-enantiomer)
Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).
Niraparib (R-enantiomer)
🥰Excellent
Purity: 99.41%
Catalog No. T12064Alias Niraparib R-enantiomer, MK 4827 (R-enantiomer)Cas No. 1038915-58-0
Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 41 € | In Stock | |
| 5 mg | 101 € | In Stock | |
| 10 mg | 177 € | In Stock | |
| 25 mg | 306 € | In Stock | |
| 50 mg | 443 € | In Stock | |
| 100 mg | 620 € | In Stock | |
| 200 mg | 835 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 112 € | In Stock |
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Niraparib Cited
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Niraparib tosylate monohyrate
T94971613220-15-7
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
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Purity:99.41%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM). |
| Targets&IC50 | PARP1:2.4 nM |
| In vitro | Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). [1]. |
| Alias | Niraparib R-enantiomer, MK 4827 (R-enantiomer) |
| Molecular Weight | 320.39 |
| Formula | C19H20N4O |
| Cas No. | 1038915-58-0 |
| Smiles | NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@H]1CCCNC1 |
| Relative Density. | 1.34 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (93.63 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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