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O-Nornuciferine

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Purity:99.86%

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COA HPLC HNMR

O-Nornuciferine

Catalog No. TN1092Cas No. 3153-55-7

O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.

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Pack Size	Price	Availability
1 mg	$81	In Stock
5 mg	$198	In Stock
10 mg	$328	In Stock
25 mg	$552	In Stock
1 mL x 10 mM (in DMSO)	$188	In Stock

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Product Introduction

Bioactivity

Description

O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.

In vitro

In an in vitro screening of herbal materials for hERG blockers using an automated two-microelectrode voltage clamp assay on Xenopus oocytes, an alkaloid fraction of Nelumbo nucifera Gaertn. (lotus) leaves induced ???50% of hERG current inhibition at 100 μg/mL. Chromatographic separation resulted in the isolation and identification of (-)-asimilobine, 1, nuciferine, 2, O-Nornuciferine, 3, N-nornuciferine, 4, and liensinine, 5. In agreement with in silico predicted ligand-target interactions, 2, 3, and 4 revealed distinct in vitro hERG blockages measured in HEK293 cells with IC50 values of 2.89, 7.91, and 9.75 μM, respectively.

Chemical Properties

Molecular Weight	281.35
Formula	C18H19NO2
Cas No.	3153-55-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (177.71 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5543 mL	17.7715 mL	35.5429 mL	177.7146 mL
5 mM	0.7109 mL	3.5543 mL	7.1086 mL	35.5429 mL
10 mM	0.3554 mL	1.7771 mL	3.5543 mL	17.7715 mL
20 mM	0.1777 mL	0.8886 mL	1.7771 mL	8.8857 mL
50 mM	0.0711 mL	0.3554 mL	0.7109 mL	3.5543 mL
100 mM	0.0355 mL	0.1777 mL	0.3554 mL	1.7771 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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