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Olorinab

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Purity:97.13%

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COA HNMR HPLC

Olorinab

Catalog No. T14302Cas No. 1268881-20-4

Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.

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Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$397	In Stock
50 mg	$589	6-8 weeks

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Product Introduction

Bioactivity

Description	Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.
In vitro	A comprehensive in vitro profile of Olorinab (APD 371) (6) shows that single digit nanomolar potency and full intrinsic efficacy are maintained in all species assessed. Olorinab (APD 371) is highly selective for CB2 over CB1 in both binding and functional assays. Olorinab (APD 371) induces efficient receptor internalization (~106% relative to the CB1/2 agonist CP55,940) in CHO cells expressing HA-tagged rat CB2 suggesting that, according to the hypothesis, Olorinab (APD 371) would be able to drive agonist-induced receptor recycling[1].
In vivo	Olorinab (APD 371) significantly increases paw withdrawal thresholds at doses ≥3 mg/kg PO (ED50=2.3 mg/kg). The analgesic effects of Olorinab (APD 371) are shown to be highly likely mediated via activity at CB2 receptors[1]. In a separate experiment, a single dose of Olorinab (APD 371) (10 mg/kg, PO) inhibits paw withdrawal threshold for up to 4 hours after administration.
Alias	APD 371

Chemical Properties

Molecular Weight	357.41
Formula	C18H23N5O3
Cas No.	1268881-20-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 180 mg/mL (503.6 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7979 mL	13.9895 mL	27.9791 mL	139.8954 mL
5 mM	0.5596 mL	2.7979 mL	5.5958 mL	27.9791 mL
10 mM	0.2798 mL	1.3990 mL	2.7979 mL	13.9895 mL
20 mM	0.1399 mL	0.6995 mL	1.3990 mL	6.9948 mL
50 mM	0.0560 mL	0.2798 mL	0.5596 mL	2.7979 mL
100 mM	0.0280 mL	0.1399 mL	0.2798 mL	1.3990 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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