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ORM-10921
🥰Excellent
Catalog No. T28267Cas No. 610782-82-6
Alias ORM10921, ORM 10921
ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies.
ORM-10921
🥰Excellent
Purity: 99.75%
Catalog No. T28267Alias ORM10921, ORM 10921Cas No. 610782-82-6
ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $397 | In Stock | |
| 5 mg | $970 | In Stock | |
| 10 mg | $1,290 | In Stock | |
| 25 mg | $1,950 | In Stock | |
| 50 mg | $2,620 | In Stock |
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Purity:99.75%
ee:98.164%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies. |
| In vivo | The role of the α2C-AR in modulating two key depression-related behaviors in the Flinders Sensitive Line (FSL) rat was studied using a dose-response analysis following subcutaneous administration with the selective α2C-AR antagonist ORM-10921 (0.03, 0.3 mg/kg), the nonselective α2-AR antagonist idazoxan (3 mg/kg), or vehicle once daily for 14 days. Behavior in the novel object recognition test forced swim test (FST), and locomotor activity test was assessed. ORM-10921 at both doses but not idazoxan significantly reversed immobility in the FST as well as attenuated cognitive deficits in FSL animals.[3] |
| Alias | ORM10921, ORM 10921 |
| Molecular Weight | 285.38 |
| Formula | C18H23NO2 |
| Cas No. | 610782-82-6 |
| Smiles | C(OC)[C@]1(C)[C@]2(C3=C(C=4C(O3)=CC=CC4)CCN2CCC1)[H] |
| Relative Density. | 1.16 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (157.68 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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