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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $39 | In Stock | |
10 mg | $55 | In Stock | |
25 mg | $98 | In Stock | |
50 mg | $168 | In Stock | |
100 mg | $272 | In Stock | |
200 mg | $396 | In Stock |
Description | PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2]. |
In vitro | PACOCF3 does not affect basal cytosolic free calcium concentrations ([Ca2+]i) at 20 μM, but a dosage between 50-250 μM triggers an increase in [Ca2+]i through the stimulation of extracellular Ca2+ entry, which can be partially inhibited by 50 μM La3+[2]. This PACOCF3-induced effect is negated when extracellular Ca2+ is removed. At a concentration of 10 μM, PACOCF3 amplifies the peak and the area under the curve of the [Ca2+]i surge elicited by 10 μM ATP and 1 μM bradykinin, by enhancing extracellular Ca2+ influx without altering internal Ca2+ release[2]. |
Alias | 1,1,1-trifluoroheptadecan-2-one, Palmityltrifluoromethylketone |
Molecular Weight | 308.42 |
Formula | C17H31F3O |
Cas No. | 141022-99-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (145.9 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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