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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $65 | In Stock | |
5 mg | $196 | In Stock | |
10 mg | $316 | In Stock | |
25 mg | $515 | In Stock | |
50 mg | $714 | In Stock | |
100 mg | $948 | In Stock | |
500 mg | Inquiry | In Stock |
Description | PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM. |
Targets&IC50 | MMP13:0.65 nM, MMP9:0.98 μM, MMP12:1.4 μM, MMP8:1.7 μM, MMP3:0.39 μM |
In vitro | PF-00356231 hydrochloride shows potency against MMP-13, MMP-3, MMP-9, and MMP-8 with IC50s of 0.65 nM, 0.39 μM, 0.98 μM, and 1.7 μM, respectively. PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH[1]. |
Molecular Weight | 464.96 |
Formula | C25H21ClN2O3S |
Cas No. | 820223-77-6 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 18.9 mg/mL (40.6 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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