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PF-04620110

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Catalog No. T6937Cas No. 1109276-89-2
Alias PF04620110, PF 04620110

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

PF-04620110

PF-04620110

🥰Excellent
Purity: 99.82%
Catalog No. T6937Alias PF04620110, PF 04620110Cas No. 1109276-89-2
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
Pack SizePriceAvailabilityQuantity
2 mg$37In Stock
5 mg$57In Stock
10 mg$106In Stock
25 mg$208In Stock
50 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$57In Stock
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Purity:99.82%
ee:100%
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Product Introduction

Bioactivity
Description
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
Targets&IC50
DGAT-1:19 nM
In vitro
Ampiroxicam (<150 μM) dose-dependently decreases the proliferation of Panc-1 cells. [1] Ampiroxicam (50 μM) results in decreased expression of Sp1, Sp3, Sp4, and VEGFR1 proteins in Panc-1 cells and L3.6pl cells as determined by Western blot analysis. Ampiroxicam (50 μM) results in increased phosphorylation of MAPK1/2 in Panc-1 cells and L3.6pl cells. [2]
In vivo
In Rats, PF-04620110 reduces plasma triglyceride levels t doses of ≥0.1 mg/kg following a lipid challenge. [1] DGAT1 inhibition by PF-04620110 causes an enrichment of polyunsaturated fatty acids within the TG class of lipids in rodents. [2]
AliasPF04620110, PF 04620110
Chemical Properties
Molecular Weight396.44
FormulaC21H24N4O4
Cas No.1109276-89-2
SmilesNc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
Relative Density.1.326 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 19.8 mg/mL (50 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5224 mL12.6122 mL25.2245 mL126.1225 mL
5 mM0.5045 mL2.5224 mL5.0449 mL25.2245 mL
10 mM0.2522 mL1.2612 mL2.5224 mL12.6122 mL
20 mM0.1261 mL0.6306 mL1.2612 mL6.3061 mL
50 mM0.0504 mL0.2522 mL0.5045 mL2.5224 mL

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