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PF-06424439 methanesulfonate

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Purity:99.79%

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COA HPLC HNMR

PF-06424439 methanesulfonate

Catalog No. T12425Cas No. 1469284-79-4

PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2.

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Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$55	In Stock
10 mg	$97	In Stock
25 mg	$197	In Stock
50 mg	$328	In Stock
100 mg	$538	In Stock
1 mL x 10 mM (in DMSO)	$66	In Stock

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Product Introduction

Bioactivity

Description	PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2.
In vivo	PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1].
Animal Research	PF-06424439 methanesulfonate (i.v.; 1 mg/kg) shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1].PF-06424439 methanesulfonate (p.o.; 60 mg/kg/day; for 3 days) reduces plasma TG and cholesterol levels and decreases nonsignificant in circulating lipids in mice (Ldlr-/-)[1].

Chemical Properties

Molecular Weight	536.05
Formula	C23H30ClN7O4S
Cas No.	1469284-79-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 249 mg/mL (464.50 mM)

H2O: 99 mg/mL (184.68 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.8655 mL	9.3275 mL	18.6550 mL	93.2749 mL
5 mM	0.3731 mL	1.8655 mL	3.7310 mL	18.6550 mL
10 mM	0.1865 mL	0.9327 mL	1.8655 mL	9.3275 mL
20 mM	0.0933 mL	0.4664 mL	0.9327 mL	4.6637 mL
50 mM	0.0373 mL	0.1865 mL	0.3731 mL	1.8655 mL
100 mM	0.0187 mL	0.0933 mL	0.1865 mL	0.9327 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc