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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $122 | In Stock | |
5 mg | $278 | In Stock | |
10 mg | $447 | In Stock | |
25 mg | $739 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,390 | In Stock | |
1 mL x 10 mM (in DMSO) | $293 | In Stock |
Description | PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM). |
In vitro | The most potent of these molecules (PI4KIIIbeta-IN-10;compound 10) was screened over a panel of nine related lipid kinases and was >200 fold selective for PI4KIIIβ across all enzymes tested. Two of the most potent and selective molecules (compound 9+10) were also the most effective antiviral compounds in a cellular model of Hepatitis C virus replication, with the best balance of antiviral potency and low cellular toxicity. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ[1]. |
Molecular Weight | 475.58 |
Formula | C22H25N3O5S2 |
Cas No. | 1881233-39-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (63.08 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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