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POMHEX
Catalog No. T36491Cas No. 2004714-34-3
Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycolytic process, and shows anticancer activity at low concentrations in an ENO1-deficient tumor model.Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is a potent and selective ENO2 inhibitor.
POMHEX
Catalog No. T36491Cas No. 2004714-34-3
Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycolytic process, and shows anticancer activity at low concentrations in an ENO1-deficient tumor model.Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is a potent and selective ENO2 inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $148 | In Stock | |
| 5 mg | $363 | In Stock | |
| 10 mg | $539 | In Stock | |
| 25 mg | $873 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 100 mg | $1,620 | In Stock |
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Purity:99.88%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycolytic process, and shows anticancer activity at low concentrations in an ENO1-deficient tumor model.Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is a potent and selective ENO2 inhibitor. |
| In vitro | POMHEX (78 nM, 8h) exhibits minimal impact on ENO1-WT glioma cells but significantly affects cells with ENO1 deletion[1]. POMHEX (0-720 nM) selectively induces energy stress, inhibits proliferation, and triggers apoptosis in ENO1-deleted glioma cells[1]. |
| In vivo | When administered intravenously or intraperitoneally at a dosage of 10 mg/kg (body weight) per day, POMHEX is well-tolerated without inducing hemolytic anemia. However, intravenous injection of POMHEX at 35 mg/kg causes lethargy and necessitates euthanasia by veterinarians[1]. POMHEX rapidly hydrolyzes to Hemi POMHEX in mouse plasma ex vivo, with a half-life of approximately 30 seconds, and in human blood ex vivo, the half-life is around 9 minutes[1]. |
| Molecular Weight | 423.4 |
| Formula | C17H30NO9P |
| Cas No. | 2004714-34-3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (118.09 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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