Shopping Cart
- Remove All
Your shopping cart is currently empty
PQR620
🥰Excellent
Catalog No. T5472Cas No. 1927857-56-4
PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.
PQR620
🥰Excellent
Purity: 97.61%
Catalog No. T5472Cas No. 1927857-56-4
PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $153 | In Stock | |
| 10 mg | $221 | In Stock | |
| 25 mg | $373 | In Stock | |
| 50 mg | $531 | In Stock | |
| 100 mg | $713 | In Stock | |
| 200 mg | $962 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $148 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "PQR620"
L-Leucine
Leu, (S)-Leucine
T3O274961-90-5
L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functions. L-Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine also prevents breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. L-Leucine is available in many foods and deficiency is rare.
- $42
Size
QTY
Rapamycin
Cited
Sirolimus, NSC-2260804, AY 22989
T153753123-88-9
Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
- $30
Size
QTY
CitedSapanisertib
TAK-228, MLN0128, INK 128
T18381224844-38-5
Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
- $34
Size
QTY
Capivasertib Cited
AZD5363
T19201143532-39-1
Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity. Capivasertib has antitumor activity for the treatment of breast cancer.
- $34
Size
QTY
CitedDihydromyricetin Cited
Ampeloptin, Ampelopsin
T299827200-12-0
Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling.
- $39
Size
QTY
CitedTacrolimus Cited
Fujimycin, FR900506, FK506
T2144104987-11-3
Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase.
- $38
Size
QTY
CitedEverolimus Cited
SDZ-RAD, RAD001
T1784159351-69-6
Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.
- $37
Size
QTY
CitedGDC0084
RG7666, Paxalisib, GDC-0084, GDC 0084
T37051382979-44-3
GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations.
- $36
Size
QTY
α-Hydroxyglutaric Acid Lithium
α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base)
T36624LIn house
α-Hydroxyglutaric Acid Lithium, converted from glutamate in microorganisms and animals, is an inhibitor of α-ketoglutarate-dependent dioxygenase and 5-methylcytosine hydroxylase, and has an inhibitory effect on ATP synthase and mTOR signaling.
- $34
Size
QTY
Bimiralisib
PQR309, PI3K-IN-2, 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
T22651225037-39-7
Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.
- $30
Size
QTY
TMBIM6 antagonist-1
BIA, BAX-inhibitor-1
T8649123134-61-2
TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor
- $85
Size
QTY
P-2281
P2281, P 2281
T282851112994-35-0
P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell function and is effective in a mouse model of human colitis.
- $158
Size
QTY
Select Batch
Purity:97.61%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2. |
| In vitro | PQR620 is a potent and selective mTOR inhibitor with >1000-fold selectivity over PI3Kα in enzymatic binding assays. In A2058 melanoma cells, it inhibits protein kinase B (pSer473) and ribosomal protein S6 (pSer235/236) phosphorylation with IC50 values of 0.2 μM and 0.1 μM, respectively. PQR620 exhibits excellent selectivity across a broad range of kinases, receptor enzymes, and ion channels, and effectively prevents cancer cell growth in the NTRC 44 cancer cell line panel, achieving a 10log(IC50) of 2.86 (nM). |
| In vivo | PQR620 exhibits favorable physico-chemical properties, leading to good oral bioavailability and excellent brain penetration. |
| Molecular Weight | 445.47 |
| Formula | C21H25F2N7O2 |
| Cas No. | 1927857-56-4 |
| Smiles | [H][C@]12CC[C@]([H])(COC1)N2c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1[C@@]2([H])CC[C@]1([H])COC2 |
| Relative Density. | 1.403 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 6.4 mg/mL (14.37 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy PQR620 | purchase PQR620 | PQR620 cost | order PQR620 | PQR620 chemical structure | PQR620 in vivo | PQR620 in vitro | PQR620 formula | PQR620 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.