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PQR620

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Purity:98.11%

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COA HPLC HNMR

PQR620

Catalog No. T5472Cas No. 1927857-56-4

PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$255	In Stock
10 mg	$369	In Stock
25 mg	$622	In Stock
50 mg	$885	In Stock
100 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$248	In Stock

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Product Introduction

Bioactivity

Description	PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.
In vitro	PQR620 is a potent and selective mTOR inhibitor, which induces >1000-fold selectivity towards mTOR over PI3Kα in enzymatic binding assays.?In A2058 melanoma cells PQR620 demonstrates inhibition of protein kinase B (pSer473) and ribosomal protein S6 (pSer235/236) phosphorylation with IC50 values of 0.2 μM and 0.1 μM, respectively.?PQR620 shows excellent selectivity over a wide panel of kinases, as well as excellent selectivity versus unrelated receptor enzymes and ion channels.?PQR620 demonstrates its potency to prevent cancer cell growth in an NTRC 44 cancer cell line panel, resulting in a 10log(IC50) of 2.86 (nM).
In vivo	The physico-chemical properties of PQR620 result in good oral bioavailability and excellent brain penetration.

Chemical Properties

Molecular Weight	445.47
Formula	C21H25F2N7O2
Cas No.	1927857-56-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.4 mg/mL (14.37 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2448 mL	11.2241 mL	22.4482 mL	112.2410 mL
5 mM	0.4490 mL	2.2448 mL	4.4896 mL	22.4482 mL
10 mM	0.2245 mL	1.1224 mL	2.2448 mL	11.2241 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc