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PQR620
Catalog No. T5472Cas No. 1927857-56-4
PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.
PQR620
Catalog No. T5472Cas No. 1927857-56-4
PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $153 | In Stock | |
| 10 mg | $221 | In Stock | |
| 25 mg | $373 | In Stock | |
| 50 mg | $531 | In Stock | |
| 100 mg | $713 | In Stock | |
| 200 mg | $962 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $148 | In Stock |
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Purity:97.61%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2. |
| In vitro | PQR620 is a potent and selective mTOR inhibitor with >1000-fold selectivity over PI3Kα in enzymatic binding assays. In A2058 melanoma cells, it inhibits protein kinase B (pSer473) and ribosomal protein S6 (pSer235/236) phosphorylation with IC50 values of 0.2 μM and 0.1 μM, respectively. PQR620 exhibits excellent selectivity across a broad range of kinases, receptor enzymes, and ion channels, and effectively prevents cancer cell growth in the NTRC 44 cancer cell line panel, achieving a 10log(IC50) of 2.86 (nM). |
| In vivo | PQR620 exhibits favorable physico-chemical properties, leading to good oral bioavailability and excellent brain penetration. |
| Molecular Weight | 445.47 |
| Formula | C21H25F2N7O2 |
| Cas No. | 1927857-56-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 6.4 mg/mL (14.37 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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