Shopping Cart

Remove All

Your shopping cart is currently empty

Pyr3

Select Batch

Purity:99.47%

Resource Download

COA HPLC HNMR

Pyr3

Catalog No. T16687Cas No. 1160514-60-2

Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$44	In Stock
5 mg	$70	In Stock
10 mg	$98	In Stock
25 mg	$226	In Stock
50 mg	$382	In Stock
100 mg	$538	In Stock
200 mg	$777	In Stock
500 mg	$1,180	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Pyr3"

Product Introduction

Bioactivity

Description	Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).
In vitro	Pyr3 becomes apparent at 0.3 μM and is almost complete at 3 μM. Ca2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells co-expressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3 (IC50 = 0.05 μM), but weakly by Pyr2 (IC50 = 2 μM) in a concentration-dependent manner[1].

Chemical Properties

Molecular Weight	456.63
Formula	C16H11Cl3F3N3O3
Cas No.	1160514-60-2

Storage & Solubility Information

Storage

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (219 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1900 mL	10.9498 mL	21.8996 mL	109.4978 mL
5 mM	0.4380 mL	2.1900 mL	4.3799 mL	21.8996 mL
10 mM	0.2190 mL	1.0950 mL	2.1900 mL	10.9498 mL
20 mM	0.1095 mL	0.5475 mL	1.0950 mL	5.4749 mL
50 mM	0.0438 mL	0.2190 mL	0.4380 mL	2.1900 mL
100 mM	0.0219 mL	0.1095 mL	0.2190 mL	1.0950 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc