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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $84 | In Stock | |
5 mg | $198 | In Stock | |
10 mg | $328 | In Stock | |
25 mg | $662 | In Stock | |
50 mg | $995 | In Stock | |
100 mg | $1,680 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor.Rheb inhibitor NR1 inhibits the phosphorylation of T389pS6K1 and promotes the phosphorylation of S473pAKT. |
In vivo | In male C57BL/6 mice aged 6-7 weeks (fasted for 16 hours), administration of the Rheb inhibitor NR1 (30 mg/kg; intraperitoneal injection; single dose) resulted in significantly reduced mTORC1 activity in both kidney and skeletal muscle. Additionally, a clear band shift for T37/464E-BP1 was observed in skeletal muscle[1]. |
Molecular Weight | 578.3 |
Formula | C25H19BrCl2N2O3S |
Cas No. | 2216763-38-9 |
Storage | store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL (34.58 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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