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Rheb inhibitor NR1
🥰Excellent
Catalog No. T16741Cas No. 2216763-38-9
Rheb inhibitor NR1 is a selective mTORC1 inhibitor that suppresses the phosphorylation of T389pS6K1 and enhances the phosphorylation of S473pAKT.
Rheb inhibitor NR1
🥰Excellent
Purity: 99.72%
Catalog No. T16741Cas No. 2216763-38-9
Rheb inhibitor NR1 is a selective mTORC1 inhibitor that suppresses the phosphorylation of T389pS6K1 and enhances the phosphorylation of S473pAKT.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $84 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $328 | In Stock | |
| 25 mg | $662 | In Stock | |
| 50 mg | $995 | In Stock | |
| 100 mg | $1,680 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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Purity:99.72%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rheb inhibitor NR1 is a selective mTORC1 inhibitor that suppresses the phosphorylation of T389pS6K1 and enhances the phosphorylation of S473pAKT. |
| In vivo | In male C57BL/6 mice aged 6-7 weeks (fasted for 16 hours), administration of the Rheb inhibitor NR1 (30 mg/kg; intraperitoneal injection; single dose) resulted in significantly reduced mTORC1 activity in both kidney and skeletal muscle. Additionally, a clear band shift for T37/464E-BP1 was observed in skeletal muscle[1]. |
| Molecular Weight | 578.3 |
| Formula | C25H19BrCl2N2O3S |
| Cas No. | 2216763-38-9 |
| Smiles | CN(C)C(=O)c1ccc(Cn2c(cc3c(Br)cc(Sc4ccc(Cl)c(Cl)c4)cc23)C(O)=O)cc1 |
| Relative Density. | 1.53 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (34.58 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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