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RK-287107
🥰Excellent
Catalog No. T16761Cas No. 2171386-10-8
RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).
RK-287107
🥰Excellent
Purity: 99.59%
Catalog No. T16761Cas No. 2171386-10-8
RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 32 € | In Stock | |
| 5 mg | 67 € | In Stock | |
| 10 mg | 106 € | In Stock | |
| 25 mg | 201 € | In Stock | |
| 50 mg | 283 € | In Stock | |
| 100 mg | 391 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 76 € | In Stock |
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Purity:99.59%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively). |
| Targets&IC50 | Tankyrase 1:14.3 nM, Tankyrase 2:10.6 nM |
| In vitro | RK-287107 (0.03-10 μM; 16 hours) also downregulates β-catenin signaling in cultured cells. 287107 (0.03-10 μM; 16 hours) induces the accumulation of tankyrase and Axin1/2. RK-87107 (0.01-10 μM; 12 hours) displays an antiproliferative effect on colorectal cancer cells harboring short adenomatous polyposis coli mutations. The 50% growth inhibition (GI50) value of RK-287107 on COLO-320DM cells is 0.449 μM. RK- [1]. |
| In vivo | In a mouse xenograft model, RK-287107 (100 and 300 mg/kg; i.p. administration; once per day; 5-days on/ 2-days off schedule for 2 weeks) inhibits tumor growth [1]. |
| Molecular Weight | 416.46 |
| Formula | C22H26F2N4O2 |
| Cas No. | 2171386-10-8 |
| Smiles | OCCN1CC2(CCN(CC2)c2nc3CCCCc3c(=O)[nH]2)c2c1cc(F)cc2F |
| Relative Density. | 1.48 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 120 mg/mL (288.14 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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