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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $57 | In Stock | |
5 mg | $118 | In Stock | |
10 mg | $187 | In Stock | |
25 mg | $354 | In Stock | |
50 mg | $497 | In Stock | |
100 mg | $687 | In Stock | |
1 mL x 10 mM (in DMSO) | $135 | In Stock |
Description | RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively). |
In vitro | RK-287107 (0.03-10 μM; 16 hours) also downregulates β-catenin signaling in cultured cells. 287107 (0.03-10 μM; 16 hours) induces the accumulation of tankyrase and Axin1/2. RK-87107 (0.01-10 μM; 12 hours) displays an antiproliferative effect on colorectal cancer cells harboring short adenomatous polyposis coli mutations. The 50% growth inhibition (GI50) value of RK-287107 on COLO-320DM cells is 0.449 μM. RK- [1]. |
In vivo | In a mouse xenograft model, RK-287107 (100 and 300 mg/kg; i.p. administration; once per day; 5-days on/ 2-days off schedule for 2 weeks) inhibits tumor growth [1]. |
Molecular Weight | 416.46 |
Formula | C22H26F2N4O2 |
Cas No. | 2171386-10-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 120 mg/mL (288.14 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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