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RO 4938581
Catalog No. T16794Cas No. 883093-10-5
RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively)).
RO 4938581
Catalog No. T16794Cas No. 883093-10-5
RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively)).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,230 | 6-8 weeks | |
| 50 mg | $1,610 | 6-8 weeks | |
| 100 mg | $2,650 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively)). |
| Targets&IC50 | GABAA α2β3γ2a:185 nM(ki), GABAA α1β3γ2a:174 nM(ki), GABAA α3β3γ2a:80 nM, GABAA α5β3γ2a:(ki)4.6 nM |
| In vivo | RO 4938581 (0.3-1 mg/kg, p.o.) reverses scopolamine-induced working memory impairment in the delayed match-to-position task [1]. |
| Molecular Weight | 352.14 |
| Formula | C13H8BrF2N5 |
| Cas No. | 883093-10-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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