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S19-1035

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Purity:100%

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COA HPLC HNMR

S19-1035

Catalog No. T67950

S19-1035 is a potent and specific inhibitor of aldo-keto reductase 1C3 (AKR1C3), displaying an inhibitory concentration (IC50) of 3.04 nM. It is primarily utilized in tumor research.

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Pack Size	Price	Availability
5 mg	$55	In Stock
10 mg	$84	In Stock
25 mg	$172	In Stock
50 mg	$278	In Stock
100 mg	$452	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock

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Product Introduction

Bioactivity

Description	S19-1035 is a potent and specific inhibitor of aldo-keto reductase 1C3 (AKR1C3), displaying an inhibitory concentration (IC50) of 3.04 nM. It is primarily utilized in tumor research.
In vitro	S19-1035 demonstrates low cytotoxicity (0-100 μM ; 72 h or 96 h) and limited antitumor efficacy when used alone.[1] S19-1035 significantly reverses the resistance of doxorubicin-resistant breast cancer cell lines when administered at 10 μM for 8 days.[1]
In vivo	Setrobuvir (200, 400, and 800 mg) BID were -2.1, -2.2, and -2.9 log10 IU/mL, respectively (vs ≤0.1 log10 IU/mL with placebo).[3]

Chemical Properties

Molecular Weight	356.80
Formula	C19H17ClN2O3
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (315.3 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8027 mL	14.0135 mL	28.0269 mL	140.1345 mL
5 mM	0.5605 mL	2.8027 mL	5.6054 mL	28.0269 mL
10 mM	0.2803 mL	1.4013 mL	2.8027 mL	14.0135 mL
20 mM	0.1401 mL	0.7007 mL	1.4013 mL	7.0067 mL
50 mM	0.0561 mL	0.2803 mL	0.5605 mL	2.8027 mL
100 mM	0.0280 mL	0.1401 mL	0.2803 mL	1.4013 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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S19-1035