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SBI-115

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Purity:99.67%

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COA HPLC HNMR

SBI-115

Catalog No. T7428Cas No. 882366-16-7

SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5

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Pack Size	Price	Availability
5 mg	$48	In Stock
10 mg	$74	In Stock
25 mg	$148	In Stock
50 mg	$232	In Stock
100 mg	$374	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Product Introduction

Bioactivity

Description	SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5
In vivo	Stimulation of cholangiocytes with TLCA following by SBI-115 treatment resulted in dose-dependent (by 32–48%) inhibition of cell proliferation.
Cell Research	cAMP was detected by the Bridge-It cAMP designer cAMP assay. Cholangiocytes (10,000/well) were incubated with TLCA, OA, C1 and C2 (all, 25 μM), SBI-115 (100 and 200 μM) and pasireotide (20 μM) for 15–30 min. Doses of drugs were chosen based on published data or dose ranging (SBI-115). Cell proliferation was determined by CellTiter 96 Aqueous One Solution Cell Proliferation Assay ?and by cell counting using the Cellometer Auto4 ?cell counter.?Cholangiocytes (2500 cells/well) were grown for 24–48 hours and then treated with TGR5 agonists (all, 25 μM), SBI-115 (100 and 200 μM) and pasireotide (20 μM) for additional 24 hours.?Alterations in cell proliferation after treatment were expressed as percent change compared to un-treated cholangiocytes in which cell proliferation was considered to be equal 100%.

Chemical Properties

Molecular Weight	340.78
Formula	C14H13ClN2O4S
Cas No.	882366-16-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (440.17 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9344 mL	14.6722 mL	29.3444 mL	146.7222 mL
5 mM	0.5869 mL	2.9344 mL	5.8689 mL	29.3444 mL
10 mM	0.2934 mL	1.4672 mL	2.9344 mL	14.6722 mL
20 mM	0.1467 mL	0.7336 mL	1.4672 mL	7.3361 mL
50 mM	0.0587 mL	0.2934 mL	0.5869 mL	2.9344 mL
100 mM	0.0293 mL	0.1467 mL	0.2934 mL	1.4672 mL

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