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Sedanolide
🥰Excellent
Catalog No. T5763Cas No. 6415-59-4
Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery.
Sedanolide
🥰Excellent
Purity: 98%
Catalog No. T5763Cas No. 6415-59-4
Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $108 | In Stock | |
| 10 mg | $160 | In Stock | |
| 25 mg | $266 | In Stock | |
| 50 mg | $395 | In Stock | |
| 100 mg | $587 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $120 | In Stock |
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery. |
| In vitro | Sedanolide suppressed J5 cell viability by inducing autophagy. Phosphoinositide 3-kinase (PI3K)-I, mammalian target of rapamycin (mTOR) and Akt protein levels decreased, whereas PI3K-III, LC3-II and Beclin-1 protein levels increased following Sedanolide treatment in J5 cells. In addition, Sedanolide treatment upregulated nuclear p53 and damage-regulated autophagy modulator (DRAM) and downregulated cytosolic p53 and Tp53-induced glycolysis and apoptosis regulator (TIGAR) expression in J5 cells. Furthermore, the cytosolic phosphorylation of inhibitor of kappa B (IκB) and nuclear p65 and the DNA-binding activity of NF-κB increased after Sedanolide treatment. These results suggest that Sedanolide induces J5 cell autophagy by regulating PI3K, p53 and NF-κB autophagy-associated signaling pathways in J5 cells. |
| Molecular Weight | 194.27 |
| Formula | C12H18O2 |
| Cas No. | 6415-59-4 |
| Smiles | CCCCC1OC(=O)C2=CCCCC12 |
| Relative Density. | 1.417g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (46.33 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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