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SHU 9119 acetate

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Purity:99.8%

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COA HPLC MS

SHU 9119 acetate

Catalog No. T16879L

SHU 9119 acetate is a well-known antagonist of human melanocortin 3 and 4 (hMC3R, hMC4R) receptors and a partial hMC5R agonist. The IC50 values of human MC3R, MC4R and MC5R is 0.23, 0.06, and 0.09 nM respectively.

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Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$383	In Stock
10 mg	$575	In Stock
25 mg	$923	In Stock
50 mg	$1,260	In Stock
1 mL x 10 mM (in DMSO)	$647	In Stock

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Product Introduction

Bioactivity

Description	SHU 9119 acetate is a well-known antagonist of human melanocortin 3 and 4 (hMC3R, hMC4R) receptors and a partial hMC5R agonist. The IC50 values of human MC3R, MC4R and MC5R is 0.23, 0.06, and 0.09 nM respectively.
In vivo	Compared with control, blocking CNS-Mcr by chronic intracerebroventricular infusion of SHU9119 (24 nmol/d for 7 days) increases food intake in ad libitum-fed rats. Weight gain of SHU9119 treated rats is significantly higher than control. SHU9119 treatment effectively increases metabolic efficiency. SHU9119 markedly increases mRNA levels of genes promoting lipogenesis and TAG storage in adipocytes, including stearoyl-CoA desaturase-1, lipoprotein lipase, acetyl-CoA carboxylase α, and fatty acid synthase. SHU9119 increases food intake (+30%) and body fat (+50%) and decreases EE by reduction in fat oxidation (?42%). Furthermore, SHU9119 impairs the uptake of VLDL-TG by BAT. In line with this, SHU9119 decreases uncoupling protein-1 levels in BAT (?60%) and induces large intracellular lipid droplets, indicative of severely disturbed BAT activity.
Alias	SHU 9119 acetate (168482-23-3 free base)

Chemical Properties

Molecular Weight	1134.29
Formula	C56H75N15O11
Cas No.

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (48.49 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8816 mL	4.4080 mL	8.8161 mL	44.0804 mL
5 mM	0.1763 mL	0.8816 mL	1.7632 mL	8.8161 mL
10 mM	0.0882 mL	0.4408 mL	0.8816 mL	4.4080 mL
20 mM	0.0441 mL	0.2204 mL	0.4408 mL	2.2040 mL

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