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SKF38393 hydrobromide
🥰Excellent
Catalog No. T23359Cas No. 20012-10-6
Alias SKF 38393 hydrobromide
SKF38393 hydrobromide is the salt form of SKF38393.SKF38393 is a dopamine D1 receptor agonist that increases the expression of Shati/Nat8L mRNA in the NAc of mice; increases the frequency of 5-hydroxytryptamine and n -methyl- D -aspartate-induced locomotion-associated ruptures in astrocytes; can mimic the dopamine-induced inhibition of colonic motility in mice; can promote locust swarming
SKF38393 hydrobromide
🥰Excellent
Catalog No. T23359Alias SKF 38393 hydrobromideCas No. 20012-10-6
SKF38393 hydrobromide is the salt form of SKF38393.SKF38393 is a dopamine D1 receptor agonist that increases the expression of Shati/Nat8L mRNA in the NAc of mice; increases the frequency of 5-hydroxytryptamine and n -methyl- D -aspartate-induced locomotion-associated ruptures in astrocytes; can mimic the dopamine-induced inhibition of colonic motility in mice; can promote locust swarming
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $128 | In Stock | |
| 25 mg | $259 | In Stock | |
| 50 mg | $383 | In Stock | |
| 100 mg | $569 | In Stock | |
| 200 mg | $816 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SKF38393 hydrobromide is the salt form of SKF38393.SKF38393 is a dopamine D1 receptor agonist that increases the expression of Shati/Nat8L mRNA in the NAc of mice; increases the frequency of 5-hydroxytryptamine and n -methyl- D -aspartate-induced locomotion-associated ruptures in astrocytes; can mimic the dopamine-induced inhibition of colonic motility in mice; can promote locust swarming |
| Targets&IC50 | D1 receptor:110 nM |
| In vitro | Methods: To assess the role of dopamine receptor subtypes in the initiation of behavioral sensitization to cocaine, the partial D1 agonist SKF-38393 (0.01-1.0 μg/side), the D2/3 agonist quinpirole (0.1-1.0 μg/side), or saline was infused once daily into the ventral tegmental area (VTA) or nucleus accumbens shell over 3 days. Results: 1.0 μg/side SKF-38393 infusion into the nucleus accumbens shell produced significant behavioral hyperactivity after both the first and last daily infusions, with no significant differences in behavioral responses between days; repeated administration of SKF-38393 into the VTA resulted in sensitization to the locomotor activating effects of cocaine.[6] |
| In vivo | Methods: To assess the role of dopamine receptor subtypes in the initiation of behavioral sensitization to cocaine, the partial D1 agonist SKF38393 hydrobromide (0.01-1.0 μg/side), the D2/3 agonist quinpirole (0.1-1.0 μg/side), or saline was infused once daily into the ventral tegmental area (VTA) or nucleus accumbens shell over 3 days. Results: 1.0 μg/side SKF38393 hydrobromide infusion into the nucleus accumbens shell produced significant behavioral hyperactivity after both the first and last daily infusions, with no significant differences in behavioral responses between days; repeated administration of SKF38393 hydrobromide into the VTA resulted in sensitization to the locomotor activating effects of cocaine.[1] |
| Alias | SKF 38393 hydrobromide |
| Molecular Weight | 336.22 |
| Formula | C16H18BrNO2 |
| Cas No. | 20012-10-6 |
| Smiles | Br.OC=1C=C2C(=CC1O)C(C=3C=CC=CC3)CNCC2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: 10 mg/mL (29.74 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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