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SKF 38393 hydrochloride

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Purity:99.1%

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COA HNMR HPLC

SKF 38393 hydrochloride

Catalog No. T6988Cas No. 62717-42-4

SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist.

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Pack Size	Price	Availability
25 mg	$50	In Stock
50 mg	$71	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock

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Product Introduction

Bioactivity

Description	SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist.
In vitro	SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4]
In vivo	SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5]
Alias	(±)-SKF-38393 hydrochloride, SKF-38393A, SKF38393 HCl

Chemical Properties

Molecular Weight	291.77
Formula	C16H17NO2·HCl
Cas No.	62717-42-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 6 mg/mL(20.56 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 45 mg/mL (154.23 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.4274 mL	17.1368 mL	34.2736 mL	171.3679 mL
5 mM	0.6855 mL	3.4274 mL	6.8547 mL	34.2736 mL
10 mM	0.3427 mL	1.7137 mL	3.4274 mL	17.1368 mL
20 mM	0.1714 mL	0.8568 mL	1.7137 mL	8.5684 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0685 mL	0.3427 mL	0.6855 mL	3.4274 mL
100 mM	0.0343 mL	0.1714 mL	0.3427 mL	1.7137 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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