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SKF 38393 hydrochloride
🥰Excellent
Catalog No. T6988Cas No. 62717-42-4
Alias SKF-38393A, SKF38393 HCl, (±)-SKF-38393 hydrochloride
SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist.
SKF 38393 hydrochloride
🥰Excellent
Purity: 99.1%
Catalog No. T6988Alias SKF-38393A, SKF38393 HCl, (±)-SKF-38393 hydrochlorideCas No. 62717-42-4
SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $50 | In Stock | |
| 50 mg | $71 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $78 | In Stock |
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Purity:99.1%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist. |
| Targets&IC50 | D1:110 nM |
| In vitro | SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4] |
| In vivo | SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5] |
| Alias | SKF-38393A, SKF38393 HCl, (±)-SKF-38393 hydrochloride |
| Molecular Weight | 291.77 |
| Formula | C16H17NO2·HCl |
| Cas No. | 62717-42-4 |
| Smiles | Cl.Oc1cc2CCNCC(c3ccccc3)c2cc1O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 6 mg/mL (20.56 mM), Heating is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 45 mg/mL (154.23 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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