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SP187

🥰Excellent
Catalog No. T16914Cas No. 615253-61-7
Alias UV4, MON-​DNJ

SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.

SP187

SP187

🥰Excellent
Purity: 99.18%
Catalog No. T16914Alias UV4, MON-​DNJCas No. 615253-61-7
SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.
Pack SizePriceAvailabilityQuantity
1 mg$196In Stock
5 mg$397In Stock
10 mg$596In Stock
25 mg$953In Stock
50 mg$1,280In Stock
100 mg$1,680In Stock
1 mL x 10 mM (in DMSO)$287In Stock
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Purity:99.18%
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Product Introduction

Bioactivity
Description
SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.
Targets&IC50
EBOV:29.97 μM, MARV:47.72 μM
In vitro
SP187 (UV-4) is evaluated in vitro for its antiviral efficacy against EBOV and MARV using a yield-plaque assay format. SP187 demonstrates antiviral activity with IC50 values of 29.97 μM and 47.72 μM against EBOV and MARV, respectively.[1]
In vivo
In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started ~1h before infection with ~1000 pfu of mouse-adapted EBOV and is repeated BID for 10 days at approximately 12-hour intervals for UV-5 or TID at approximately 8-hour intervals for SP187. The selected doses and schedules are based on tolerability studies in naïve mice. No efficacy is observed in the iminosugar-treated mice as compared to the vehicle control.[1]
AliasUV4, MON-​DNJ
Chemical Properties
Molecular Weight319.44
FormulaC16H33NO5
Cas No.615253-61-7
SmilesCOCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Relative Density.1.128 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 63.89 mg/mL (200 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1305 mL15.6524 mL31.3048 mL156.5239 mL
5 mM0.6261 mL3.1305 mL6.2610 mL31.3048 mL
10 mM0.3130 mL1.5652 mL3.1305 mL15.6524 mL
20 mM0.1565 mL0.7826 mL1.5652 mL7.8262 mL
50 mM0.0626 mL0.3130 mL0.6261 mL3.1305 mL
100 mM0.0313 mL0.1565 mL0.3130 mL1.5652 mL

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