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SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $196 | In Stock | |
5 mg | $397 | In Stock | |
10 mg | $596 | In Stock | |
25 mg | $953 | In Stock | |
50 mg | $1,280 | In Stock | |
100 mg | $1,680 | In Stock | |
1 mL x 10 mM (in DMSO) | $287 | In Stock |
Description | SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses. |
Targets&IC50 | EBOV:29.97 μM, MARV:47.72 μM |
In vitro | SP187 (UV-4) is evaluated in vitro for its antiviral efficacy against EBOV and MARV using a yield-plaque assay format. SP187 demonstrates antiviral activity with IC50 values of 29.97 μM and 47.72 μM against EBOV and MARV, respectively.[1] |
In vivo | In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started ~1h before infection with ~1000 pfu of mouse-adapted EBOV and is repeated BID for 10 days at approximately 12-hour intervals for UV-5 or TID at approximately 8-hour intervals for SP187. The selected doses and schedules are based on tolerability studies in naïve mice. No efficacy is observed in the iminosugar-treated mice as compared to the vehicle control.[1] |
Alias | UV4, MON-DNJ |
Molecular Weight | 319.44 |
Formula | C16H33NO5 |
Cas No. | 615253-61-7 |
Smiles | COCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |
Relative Density. | 1.128 g/cm3 (Predicted) |
Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 63.89 mg/mL (200 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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