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SRT 1460

🥰Excellent
Catalog No. T8346Cas No. 925432-73-1
Alias SRT1460

SRT 1460 is a SIRT1 activator.

SRT 1460

SRT 1460

🥰Excellent
Purity: 97.62%
Catalog No. T8346Alias SRT1460Cas No. 925432-73-1
SRT 1460 is a SIRT1 activator.
Pack SizePriceAvailabilityQuantity
2 mg52 €In Stock
5 mg75 €In Stock
10 mg112 €In Stock
25 mg168 €In Stock
50 mg251 €In Stock
100 mg377 €In Stock
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Purity:97.62%
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Product Introduction

Bioactivity
Description
SRT 1460 is a SIRT1 activator.
Targets&IC50
SIRT1:2.9 μM (EC1.5)
In vitro
SRT1460 inhibited cell growth and survival of pancreatic cancer cells[1].
Cell Research
Patu8988t (pancreatic cancer cells), Panc-1 (pancreatic cancer cells), SU86.86 (pancreatic cancer cells), HPDE cells.?Concentration:2 μM, 4 μM, 6 μM.?Incubation Time:72 hours[1]
AliasSRT1460
Chemical Properties
Molecular Weight507.6
FormulaC26H29N5O4S
Cas No.925432-73-1
SmilesOC(=O)C(F)(F)F.COc1cc(cc(OC)c1OC)C(=O)Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 5.08 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9701 mL9.8503 mL19.7006 mL98.5028 mL
5 mM0.3940 mL1.9701 mL3.9401 mL19.7006 mL
10 mM0.1970 mL0.9850 mL1.9701 mL9.8503 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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