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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $215 | In Stock | |
5 mg | $537 | In Stock | |
10 mg | $775 | In Stock | |
25 mg | $1,190 | In Stock | |
50 mg | $1,590 | In Stock |
Description | SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells. |
In vitro | SSK1 (0.5 μM; 12-72 h) is activated by lysosomal β-galactosidase, selectively kills senescent cells by activating p38 MAPK, and inducing apoptosis[1]. |
In vivo | Lung-injured mice (3-6 months old) received intratracheal administration of bleomycin (1.5 mg/kg) and were subjected to intraperitoneal injection of SSK1 (0.5 mg/kg) or vehicle (DMSO) for two consecutive days each week for 4 weeks. The results indicate that SSK1 can eliminate SA-β-gal-positive senescent cells and reduce aging-related markers in vivo[1]. |
Molecular Weight | 788.61 |
Formula | C31H34F2N4O18 |
Cas No. | 2629250-69-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 150 mg/mL (190.20 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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