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SSK1

SSK1
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Purity:99.83%
ee:100%

SSK1

Catalog No. T37450Cas No. 2629250-69-5
SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells.
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Pack SizePriceAvailabilityQuantity
1 mg$215In Stock
5 mg$537In Stock
10 mg$775In Stock
25 mg$1,190In Stock
50 mg$1,590In Stock
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Product Introduction

Bioactivity
Description
SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells.
In vitro
SSK1 (0.5 μM; 12-72 h) is activated by lysosomal β-galactosidase, selectively kills senescent cells by activating p38 MAPK, and inducing apoptosis[1].
In vivo
Lung-injured mice (3-6 months old) received intratracheal administration of bleomycin (1.5 mg/kg) and were subjected to intraperitoneal injection of SSK1 (0.5 mg/kg) or vehicle (DMSO) for two consecutive days each week for 4 weeks. The results indicate that SSK1 can eliminate SA-β-gal-positive senescent cells and reduce aging-related markers in vivo[1].
Chemical Properties
Molecular Weight788.61
FormulaC31H34F2N4O18
Cas No.2629250-69-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 150 mg/mL (190.20 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2681 mL6.3403 mL12.6805 mL63.4027 mL
5 mM0.2536 mL1.2681 mL2.5361 mL12.6805 mL
10 mM0.1268 mL0.6340 mL1.2681 mL6.3403 mL
20 mM0.0634 mL0.3170 mL0.6340 mL3.1701 mL
50 mM0.0254 mL0.1268 mL0.2536 mL1.2681 mL
100 mM0.0127 mL0.0634 mL0.1268 mL0.6340 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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