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Sumanirole maleate
🥰Excellent
Catalog No. TQ0140Cas No. 179386-44-8
Alias U-95666E, U95666E, PNU-95666, PNU95666
Sumanirole maleate (PNU-95666E) is a D2 receptor full agonist with high selectivity (ED50 = 46 nM) that improves motor function in patients with Parkinson's disease and plays an important role in the study of restless legs syndrome.
Sumanirole maleate
🥰Excellent
Catalog No. TQ0140Alias U-95666E, U95666E, PNU-95666, PNU95666Cas No. 179386-44-8
Sumanirole maleate (PNU-95666E) is a D2 receptor full agonist with high selectivity (ED50 = 46 nM) that improves motor function in patients with Parkinson's disease and plays an important role in the study of restless legs syndrome.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $83 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Sumanirole maleate (PNU-95666E) is a D2 receptor full agonist with high selectivity (ED50 = 46 nM) that improves motor function in patients with Parkinson's disease and plays an important role in the study of restless legs syndrome. |
| Targets&IC50 | D2 receptor:46 nM (EC50) |
| Alias | U-95666E, U95666E, PNU-95666, PNU95666 |
| Molecular Weight | 319.31 |
| Formula | C15H17N3O5 |
| Cas No. | 179386-44-8 |
| Smiles | C(=C\C(O)=O)\C(O)=O.O=C1N2C3=C(C[C@@H](NC)C2)C=CC=C3N1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (125.27 mM), Sonication is recommended. H2O: 8 mg/mL (25.05 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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