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Cariprazine hydrochloride

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Purity:100%

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COA HPLC HNMR

Cariprazine hydrochloride

Catalog No. T8382Cas No. 1083076-69-0

Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)

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Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$47	In Stock
25 mg	$76	In Stock
50 mg	$116	In Stock
100 mg	$173	In Stock
500 mg	$428	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)
In vivo	Cariprazine occupied D(2)/D(3) receptors in a dose-dependent and saturable manner, with the lowest dose occupying ~5% of receptors and the highest dose showing more than 90% occupancy. 5-HT(1A) receptor occupancy was considerably lower compared with D(2)/D(3) occupancy at the same doses, with a maximal value of ~30% for the raphe nuclei[1].
Animal Research	Three monkeys using the following PET radioligands: [(11)C]MNPA (an agonist at D(2) and D(3) receptors), [(11)C]raclopride (an antagonist at D(2) and D(3) receptors), and [(11)C]WAY-100635 (an antagonist at 5-HT(1A) receptors). During each experimental day, the first PET measurement was a baseline study, the second after a low dose of cariprazine, and the third after the administration of a high dose[1].
Alias	Cariprazine HCl, RGH188 hydrochloride

Chemical Properties

Molecular Weight	463.87
Formula	C21H33Cl3N4O
Cas No.	1083076-69-0

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	DMSO: < 1mg/ml (insoluble）

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