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Cariprazine hydrochloride

🥰Excellent
Catalog No. T8382Cas No. 1083076-69-0
Alias RGH188 hydrochloride, Cariprazine HCl

Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)

Cariprazine hydrochloride

Cariprazine hydrochloride

🥰Excellent
Purity: 100%
Catalog No. T8382Alias RGH188 hydrochloride, Cariprazine HClCas No. 1083076-69-0
Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)
Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$47In Stock
25 mg$76In Stock
50 mg$116In Stock
100 mg$173In Stock
500 mg$428In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)
Targets&IC50
D2 receptor:0.49 nM (Ki) , 5-HT1A receptor:2.6 nM (Ki), D3 receptor:0.085 nM (Ki)
In vivo
Cariprazine occupied D(2)/D(3) receptors in a dose-dependent and saturable manner, with the lowest dose occupying ~5% of receptors and the highest dose showing more than 90% occupancy. 5-HT(1A) receptor occupancy was considerably lower compared with D(2)/D(3) occupancy at the same doses, with a maximal value of ~30% for the raphe nuclei[1].
Animal Research
Three monkeys using the following PET radioligands: [(11)C]MNPA (an agonist at D(2) and D(3) receptors), [(11)C]raclopride (an antagonist at D(2) and D(3) receptors), and [(11)C]WAY-100635 (an antagonist at 5-HT(1A) receptors). During each experimental day, the first PET measurement was a baseline study, the second after a low dose of cariprazine, and the third after the administration of a high dose[1].
AliasRGH188 hydrochloride, Cariprazine HCl
Chemical Properties
Molecular Weight463.87
FormulaC21H33Cl3N4O
Cas No.1083076-69-0
SmilesCl.CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: < 1 mg/mL (insoluble), Sonication is recommended.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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