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Talquetamab
🥰Excellent
Catalog No. T76882Cas No. 2226212-40-2
Alias JNJ-7564, JNJ-64407564
Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.
Talquetamab
🥰Excellent
Purity: 99.7% (SEC-HPLC)
Catalog No. T76882Alias JNJ-7564, JNJ-64407564Cas No. 2226212-40-2
Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $289 | In Stock | |
| 2 mg | $437 | In Stock | |
| 5 mg | $723 | In Stock | |
| 10 mg | $1,160 | In Stock | |
| 25 mg | $1,720 | In Stock | |
| 50 mg | $2,320 | In Stock | |
| 100 mg | $3,130 | In Stock |
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CitedSelect Batch
Concentration:4.49 mg/mL
Purity:99.7% (SEC-HPLC)
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity. |
| In vitro | Talquetamab, at concentrations ranging from 0.00128 to 4.0 μg/mL for 48 hours, effectively induces lysis of multiple myeloma cells. This induction is accompanied by a significant dose-dependent increase in the proportion of activated CD4+ and CD8+ T cells, as well as elevated levels of granule enzyme B and inflammatory cytokines such as IL-6, IL-8, and TNF-α [2]. |
| In vivo | Talquetamab (JNJ-64407564), administered subcutaneously or intravenously at doses ranging from 0.1 to 50 µg, exhibits significant anti-tumor activity in H929 and MM mouse models [1]. |
| Alias | JNJ-7564, JNJ-64407564 |
| Molecular Weight | 144.59 kDa |
| Cas No. | 2226212-40-2 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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