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Targapremir-210
🥰Excellent
Catalog No. T16991Cas No. 1049722-30-6
Alias TGP-210
Targapremir-210 (TGP-210) is a selective and potent inhibitor of miRNA-210 (miRNA-210), which inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.
Targapremir-210
🥰Excellent
Purity: 98.00%
Catalog No. T16991Alias TGP-210Cas No. 1049722-30-6
Targapremir-210 (TGP-210) is a selective and potent inhibitor of miRNA-210 (miRNA-210), which inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $232 | In Stock |
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Purity:98.00%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Targapremir-210 (TGP-210) is a selective and potent inhibitor of miRNA-210 (miRNA-210), which inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells. |
| Targets&IC50 | miR-210:200 nM |
| In vitro | Targapremir-210 selectively reduces mature miR-210 levels in MDA-MB-231 cells under hypoxic conditions, achieving an IC50 of approximately 200 nM[1]. This compound specifically induces apoptosis in MDA-MB-231 cells exposed to hypoxia at 200 nM, while it does not trigger apoptosis in cells cultivated in normoxic environments[1]. |
| In vivo | In vivo, a single intraperitoneal injection of Targapremir-210 (100 μL of 200 nM) impedes the proliferation of MDA-MB-231 triple-negative breast cancer (TNBC) cells. Targapremir-210 successfully reaches the tumor and sustains its presence throughout the entire 21-day period, leading to a reduction in tumor burden in a TNBC mouse model[1]. |
| Alias | TGP-210 |
| Molecular Weight | 592.69 |
| Formula | C32H36N10O2 |
| Cas No. | 1049722-30-6 |
| Smiles | CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1ccc2nc([nH]c2c1)-c1cccc(OCCCC(=O)NCCCN=[N+]=[N-])c1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (168.72 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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