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Targapremir-210

Catalog No. T16991Cas No. 1049722-30-6
Alias TGP-210

Targapremir-210 (TGP-210) is a selective and potent inhibitor of miRNA-210 (miRNA-210), which inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.

Targapremir-210

Targapremir-210

Purity: 98.00%
Catalog No. T16991Alias TGP-210Cas No. 1049722-30-6
Targapremir-210 (TGP-210) is a selective and potent inhibitor of miRNA-210 (miRNA-210), which inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.
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1 mg$232In Stock
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Purity:98.00%
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Product Introduction

Bioactivity
Description
Targapremir-210 (TGP-210) is a selective and potent inhibitor of miRNA-210 (miRNA-210), which inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.
Targets&IC50
miR-210:200 nM
In vitro
Targapremir-210 selectively reduces mature miR-210 levels in MDA-MB-231 cells under hypoxic conditions, achieving an IC50 of approximately 200 nM[1]. This compound specifically induces apoptosis in MDA-MB-231 cells exposed to hypoxia at 200 nM, while it does not trigger apoptosis in cells cultivated in normoxic environments[1].
In vivo
In vivo, a single intraperitoneal injection of Targapremir-210 (100 μL of 200 nM) impedes the proliferation of MDA-MB-231 triple-negative breast cancer (TNBC) cells. Targapremir-210 successfully reaches the tumor and sustains its presence throughout the entire 21-day period, leading to a reduction in tumor burden in a TNBC mouse model[1].
AliasTGP-210
Chemical Properties
Molecular Weight592.69
FormulaC32H36N10O2
Cas No.1049722-30-6
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (168.72 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6872 mL8.4361 mL16.8722 mL84.3611 mL
5 mM0.3374 mL1.6872 mL3.3744 mL16.8722 mL
10 mM0.1687 mL0.8436 mL1.6872 mL8.4361 mL
20 mM0.0844 mL0.4218 mL0.8436 mL4.2181 mL
50 mM0.0337 mL0.1687 mL0.3374 mL1.6872 mL
100 mM0.0169 mL0.0844 mL0.1687 mL0.8436 mL

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