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TC-I 2014

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Purity:98.75%

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COA HPLC HNMR

TC-I 2014

Catalog No. T17006Cas No. 1221349-53-6

TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine, human and rat channels respectively).

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Pack Size	Price	Availability
1 mg	$116	In Stock
5 mg	$287	In Stock
10 mg	$428	In Stock
25 mg	$686	In Stock
50 mg	$969	In Stock
100 mg	$1,280	In Stock
500 mg	$2,620	In Stock

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Product Introduction

Bioactivity

Description	TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine, human and rat channels respectively).
In vitro	TC-I 2014 effectively inhibits cold-induced TRPM8 currents in HEK293 cells stably expressing canine or human TRPM8 (IC50: 0.413 and 1 nM, respectively) [1].
In vivo	TC-I 2014 (10 mg/kg, Orally once) fully avoids icilin-induced WDS [1].

Chemical Properties

Molecular Weight	467.41
Formula	C23H19F6N3O
Cas No.	1221349-53-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (481.4 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1394 mL	10.6972 mL	21.3945 mL	106.9725 mL
5 mM	0.4279 mL	2.1394 mL	4.2789 mL	21.3945 mL
10 mM	0.2139 mL	1.0697 mL	2.1394 mL	10.6972 mL
20 mM	0.1070 mL	0.5349 mL	1.0697 mL	5.3486 mL
50 mM	0.0428 mL	0.2139 mL	0.4279 mL	2.1394 mL
100 mM	0.0214 mL	0.1070 mL	0.2139 mL	1.0697 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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