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TET-13
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Catalog No. T203682
TET-13 is a positive allosteric modulator of the GABAA receptor with an EC50 of 5.65 μM, which is more potent than Etomidate (EC50: 9.29 μM). It exhibits strong anesthetic effects in both mice and rats, with an ED50 of 0.48 mg/kg in mice and 0.69 mg/kg in rats.
TET-13
TET-13
😃Good
Catalog No. T203682
TET-13 is a positive allosteric modulator of the GABAA receptor with an EC50 of 5.65 μM, which is more potent than Etomidate (EC50: 9.29 μM). It exhibits strong anesthetic effects in both mice and rats, with an ED50 of 0.48 mg/kg in mice and 0.69 mg/kg in rats.
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Product Introduction
Bioactivity
Chemical Properties
| Description | TET-13 is a positive allosteric modulator of the GABAA receptor with an EC50 of 5.65 μM, which is more potent than Etomidate (EC50: 9.29 μM). It exhibits strong anesthetic effects in both mice and rats, with an ED50 of 0.48 mg/kg in mice and 0.69 mg/kg in rats. |
| In vitro | TET-13 (1 mg/mL, 0-30 min) is rapidly metabolized in the plasma of SD rats, with a half-life (T 1/2) of 0.48 minutes. |
| In vivo | TET-13 exhibits potent anesthetic effects in both mice and rats, with an ED50 of 0.48 mg/kg and 0.69 mg/kg respectively, through intravenous administration (mice: 1.2 mg/kg, rats: 1.725 mg/kg). It offers a quicker recovery than etomidate. In rats, TET-13 (1.38 mg/kg, intravenous) does not significantly inhibit serum corticosterone, found at a concentration of 970.12 nM. Continuous infusion of TET-13 at 22 mg/kg/h results in shorter recovery and ambulation times compared to etomidate after 0.5, 1, and 2 hours in rats. |
| Molecular Weight | 304.36 |
| Formula | C15H16N2O3S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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