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TfR-1-IN-1
🥰Excellent
Catalog No. T89857Cas No. 1643444-62-5
TfR-1-IN-1 is a transferrin receptor 1 (TfR-1) inhibitor, also an Fe(III) salivary phenol complex, with anticancer activity. It induces apoptosis, inhibits the growth of tumor cells and normal cells, and is used in studies of leukemia.
TfR-1-IN-1
🥰Excellent
Purity: 96.96%
Catalog No. T89857Cas No. 1643444-62-5
TfR-1-IN-1 is a transferrin receptor 1 (TfR-1) inhibitor, also an Fe(III) salivary phenol complex, with anticancer activity. It induces apoptosis, inhibits the growth of tumor cells and normal cells, and is used in studies of leukemia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $971 | In Stock |
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Purity:96.96%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TfR-1-IN-1 is a transferrin receptor 1 (TfR-1) inhibitor, also an Fe(III) salivary phenol complex, with anticancer activity. It induces apoptosis, inhibits the growth of tumor cells and normal cells, and is used in studies of leukemia. |
| In vitro | TfR-1-IN-1 significantly decreased the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231) and leukemia (HL-60) cell lines, with IC50 values of 0.51, 0.46 and 0.48 μM, respectively. [1] |
| Molecular Weight | 441.62 |
| Formula | C20H12ClF2FeN2O2 |
| Cas No. | 1643444-62-5 |
| Smiles | FC1=CC=CC=2[O-][Fe+3]34([Cl-])[O-]C5=CC=CC(F)=C5C=[N]4C6=CC=CC=C6[N]3=CC12 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (22.64 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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