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TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 92 € | In Stock | |
5 mg | 226 € | In Stock | |
10 mg | 369 € | In Stock | |
25 mg | 629 € | In Stock | |
50 mg | 897 € | In Stock | |
1 mL x 10 mM (in DMSO) | 255 € | In Stock |
Description | TP-0427736 is a novel potent and selective ALK5 inhibitor (IC50: 2.72 nM). P0427736 was 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates the anagen phase i |
Targets&IC50 | ALK5:2.72 nM |
Alias | TP-427736, TP427736, TP-0427736 |
Molecular Weight | 298.39 |
Formula | C14H10N4S2 |
Cas No. | 864374-00-5 |
Smiles | CC=1N=C(C2=C(NC=N2)C=3C=C4C(=CC3)N=CS4)SC1 |
Relative Density. | 1.439 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 65 mg/ml (217.84 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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