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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
5 mg | $77 | In Stock | |
10 mg | $126 | In Stock | |
25 mg | $217 | In Stock | |
50 mg | $343 | In Stock | |
100 mg | $571 | In Stock | |
1 mL x 10 mM (in DMSO) | $88 | In Stock |
Description | TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes. |
In vitro | TRPM8 antagonist 2 (Compound 14) is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes. TRPM8 antagonist 2 potently inhibits menthol-induced increase in intracellular Ca2+ levels in Ca2+ fluorimetric assays in HEK293 cells stably expressing the rat isoform of TRPM8 channels (IC50, 40 nM). |
In vivo | TRPM8 antagonist 2, administered subcutaneously at doses of 1, 10, and 30 mg/kg, demonstrates significant, dose-dependent antinociceptive effects and reduces wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at the 30 mg/kg dosage. Additionally, at lower doses of 0.1 and 1 μg, it effectively mitigates Oxaliplatin (OXP)-induced cold allodynia in mice. |
Molecular Weight | 398.5 |
Formula | C26H26N2O2 |
Cas No. | 259674-19-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 160 mg/mL (401.51 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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