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Uridine triacetate

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Purity:99.94%

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COA HPLC HNMR

Uridine triacetate

Catalog No. T21327Cas No. 4105-38-8

Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine), an orally active prodrug of uridine, is efficiently absorbed in the gut and swiftly deacetylated in the circulation to release free uridine. It is utilized in the research of 5-fluorouracil (5-FU) and capecitabine toxicity, particularly targeting early-onset cardiac or central nervous system (CNS) complications.

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Pack Size	Price	Availability
50 mg	$30	In Stock
100 mg	$39	In Stock
200 mg	$55	In Stock
500 mg	$91	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine), an orally active prodrug of uridine, is efficiently absorbed in the gut and swiftly deacetylated in the circulation to release free uridine. It is utilized in the research of 5-fluorouracil (5-FU) and capecitabine toxicity, particularly targeting early-onset cardiac or central nervous system (CNS) complications.
In vitro	Uridine triacetate inhibits [3H]uridine uptake in ENT1 and ENT2 overexpressed HeLa cells, with IC50s of 28.4 μM and 228.4 μM respectively[4].
In vivo	Uridine triacetate (2 g/kg, oral gavage, every 8 h for 15 total doses) improves survival and reduced toxicity in 5-FU overdose mice. Uridine triacetate (2 g/kg, oral gavage, every 8 h for 15 total doses) improves survival and reduced 5-FU toxicity in DPD deficiency mice[3].
Alias	RG 2133 triacetate, PN-401, Tri-O-acetyluridine, PN401, RG 2133, RG-2133, PN 401, RG2133, RG2133 triacetate

Chemical Properties

Molecular Weight	370.31
Formula	C15H18N2O9
Cas No.	4105-38-8

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 90mg/mL (243mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7004 mL	13.5022 mL	27.0044 mL	135.0220 mL
5 mM	0.5401 mL	2.7004 mL	5.4009 mL	27.0044 mL
10 mM	0.2700 mL	1.3502 mL	2.7004 mL	13.5022 mL
20 mM	0.1350 mL	0.6751 mL	1.3502 mL	6.7511 mL
50 mM	0.0540 mL	0.2700 mL	0.5401 mL	2.7004 mL
100 mM	0.0270 mL	0.1350 mL	0.2700 mL	1.3502 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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