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VU 0357121
🥰Excellent
Catalog No. T6725Cas No. 433967-28-3
VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
VU 0357121
🥰Excellent
Purity: 99.99%
Catalog No. T6725Cas No. 433967-28-3
VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $54 | In Stock | |
| 10 mg | $87 | In Stock | |
| 25 mg | $185 | In Stock | |
| 50 mg | $369 | In Stock | |
| 100 mg | $555 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $54 | In Stock |
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Purity:99.99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
| Targets&IC50 | mGluR5:30 nM(EC50) |
| In vitro | VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. [1] VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. [2] |
| Molecular Weight | 305.32 |
| Formula | C17H17F2NO2 |
| Cas No. | 433967-28-3 |
| Smiles | CCCCOC1=CC=C(C=C1)C(=O)NC1=CC=C(F)C=C1F |
| Relative Density. | 1.220 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 30.5 mg/mL (100 mM) DMSO: 30.5 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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