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YM-46303
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Catalog No. T13370Cas No. 171722-81-9
YM-46303 is a selective and potent muscarinic receptor antagonist that exhibits high affinity for the M3 receptor.YM-46303 can be used to study bradycardia in medullary rats.
YM-46303
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Purity: 100%
Catalog No. T13370Cas No. 171722-81-9
YM-46303 is a selective and potent muscarinic receptor antagonist that exhibits high affinity for the M3 receptor.YM-46303 can be used to study bradycardia in medullary rats.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $700 | 6-8 weeks | |
| 5 mg | $1,800 | 6-8 weeks |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | YM-46303 is a selective and potent muscarinic receptor antagonist that exhibits high affinity for the M3 receptor.YM-46303 can be used to study bradycardia in medullary rats. |
| In vivo | YM-46303, when compared to oxybutynin, exhibits approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, along with about a 5-fold greater selectivity for urinary bladder contraction over salivary secretion in rats. Evaluation of antimuscarinic effects on bradycardia and pressor responses in pithed rats, as well as on tremor in mice, reveals that YM-46303 could be valuable for treating urinary urge incontinence. It functions as a bladder-selective M3 antagonist with potent activities and fewer side effects[1]. In vivo, YM-46303 demonstrates selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. Additionally, it shows potent activity in a guinea pig model of methacholine-induced bronchospasm upon intravenous administration[1]. |
| Molecular Weight | 358.86 |
| Formula | C20H23ClN2O2 |
| Cas No. | 171722-81-9 |
| Smiles | Cl.O=C(OC12CCN(CC1)CC2)NC=3C=CC=CC3C=4C=CC=CC4 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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