Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23:α-Klotho interaction.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 350.00 | |
5 mg | In stock | $ 828.00 | |
10 mg | In stock | $ 1,130.00 | |
25 mg | In stock | $ 1,590.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 | |
500 mg | In stock | $ 4,900.00 |
Description | ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23:α-Klotho interaction. |
Targets&IC50 | ERK:5 μM |
In vitro |
ZINC12409120 (1 nM-0.1 mM; 5 h) inhibits ERK reporter activities mediated by FGF23 (1 μM), with an IC50 of 5 μM.[1] ZINC12409120 (10 μM; 5 h) specifically inhibits ERK activity mediated by FGF23:α-Klotho instead of EGF-mediated ERK activation and exhibits no inhibitory effect on EGFR tyrosine kinase or EGF/EGFR interaction.[1] |
Synonyms | R-4584 |
Molecular Weight | 344.37 |
Formula | C20H16N4O2 |
CAS No. | 1010888-06-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ZINC12409120 1010888-06-8 MAPK ERK R-4584 ZINC-12409120 ZINC 12409120 R4584 R 4584 inhibitor inhibit