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(R)-Propranolol hydrochloride

Catalog No. T20898 CAS 13071-11-9

Synonyms: Dexpropranolol hydrochloride, (R)-(+)-Propranolol

(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.

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(R)-Propranolol hydrochloride Chemical Structure

(R)-Propranolol hydrochloride, CAS 13071-11-9

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1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.01%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.
Targets&IC50	β2-adrenoceptor:0.8 nM(Ki), β1-adrenoceptor:1.8 nM(Ki)
In vivo	Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species[4]. Administration of 10 mg/kg (R)-Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation[4].

Synonyms	Dexpropranolol hydrochloride, (R)-(+)-Propranolol
Molecular Weight	295.8
Formula	C16H22ClNO2
CAS No.	13071-11-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 14.79 mg/mL (50 mM), Sonication is recommended.

DMSO: 60 mg/ml (202.84 mM)

References and Literature

1. Cocker PJ, Lin MY, Tremblay M, Kaur S, Winstanley CA. The β-adrenoceptor blocker propranolol ameliorates compulsive-like gambling behaviour in a rodent slot machine task:implications for iatrogenic gambling disorder. Eur J Neurosci. 2018 Jul 17. 2. Bührer C, Erdeve Ö, Bassler D, Bar-Oz B. Oral propranolol for prevention of threshold retinopathy of prematurity (ROPROP):protocol of a randomised controlled trial. BMJ Open. 2018 Jul 6;8(7):e021749. 3. Zhu X, Guo X, Liu D, Gong Y, Sun J, Dong C. Promotion of Propranolol Delivery to Hemangiomas by Using Anti-VEGFR Antibody-Conjugated Poly(lactic-co-glycolic acid) Nanoparticles. J Biomed Nanotechnol. 2017 Dec 1;13(12):1694-1705. 4. AM, Cullum VA. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br J Pharmacol. 1968 Sep;34(1):43-55.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library Adrenergic Receptor-Targeted Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Anti-Cancer Compound Library Neurotransmitter Receptor Compound Library Anti-Alzheimer's Disease Compound Library

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Keywords

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