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(RS)-(Tetrazol-5-yl)glycine
Catalog No. T16801Cas No. 138199-51-6
Alias LY 285265, D,L-(tetrazol-5-yl)glycine
(RS)-(Tetrazol-5-yl)glycine (LY 285265) [(D,L-(tetrazol-5-yl)glycine] is an effective and selective N-methyl-D-aspartate receptor agonist with EC50s of 99 nM for GluN1/GluN2D and 1.7 μM for GluN1/GluN2A.
(RS)-(Tetrazol-5-yl)glycine
Catalog No. T16801Alias LY 285265, D,L-(tetrazol-5-yl)glycineCas No. 138199-51-6
(RS)-(Tetrazol-5-yl)glycine (LY 285265) [(D,L-(tetrazol-5-yl)glycine] is an effective and selective N-methyl-D-aspartate receptor agonist with EC50s of 99 nM for GluN1/GluN2D and 1.7 μM for GluN1/GluN2A.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $36 | In Stock | |
| 10 mg | $58 | In Stock | |
| 25 mg | $143 | In Stock | |
| 50 mg | $247 | In Stock | |
| 100 mg | $353 | In Stock | |
| 200 mg | $495 | In Stock |
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Purity:99.89%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (RS)-(Tetrazol-5-yl)glycine (LY 285265) [(D,L-(tetrazol-5-yl)glycine] is an effective and selective N-methyl-D-aspartate receptor agonist with EC50s of 99 nM for GluN1/GluN2D and 1.7 μM for GluN1/GluN2A. |
| Targets&IC50 | GluN1/GluN2A:1.7 μM(EC50), GluN1/GluN2D:(EC50)99 nM |
| In vitro | (RS)-(Tetrazol-5-yl)glycine does not significantly inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM). It displaces NMDA receptor binding to rat brain membranes using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands [1]. |
| In vivo | (RS)-(Tetrazol-5-yl)glycine is a potent convulsant in neonatal rats (ED50=0.071 mg/kg; i.p.) and induces seizure responses and Fos in NR1+/+ and NR1-/- mice (1.25, 1.5 mg/kg; IP) [1][3]. |
| Alias | LY 285265, D,L-(tetrazol-5-yl)glycine |
| Molecular Weight | 143.1 |
| Formula | C3H5N5O2 |
| Cas No. | 138199-51-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: < 1.43 mg/mL (10 mM, insoluble or slightly soluble)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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