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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mL x 10 mM (in DMSO) | $52 | 7-10 days |
Description | (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine, a full agonist of the dopamine receptor and a partial agonist of the 5-HT1A receptor. |
Targets&IC50 | D2 receptor:13.5 nM (Ki), 5-HT1A receptor:30 nM (Ki), D5 receptor:5.4 nM (Ki), D4 receptor:3.9-15 nM (Ki), D1 receptor:83 nM (Ki), 5-HT2B receptor:27 nM (Ki), D3 receptor:0.71 nM (Ki) |
In vitro | In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7)[1]. Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+?toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone[4]. . |
Molecular Weight | 351.93 |
Formula | C19H26ClNOS |
Cas No. | 102120-99-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (142.07 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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