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(Rac)-Rotigotine hydrochloride
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(Rac)-Rotigotine hydrochloride
Catalog No. T12676Cas No. 102120-99-0
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine, a full agonist of the dopamine receptor and a partial agonist of the 5-HT1A receptor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mL x 10 mM (in DMSO) | $52 | 7-10 days |
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CitedProduct Introduction
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Storage & Solubility Information
| Description | (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine, a full agonist of the dopamine receptor and a partial agonist of the 5-HT1A receptor. |
| Targets&IC50 | D2 receptor:13.5 nM (Ki), 5-HT1A receptor:30 nM (Ki), D5 receptor:5.4 nM (Ki), D4 receptor:3.9-15 nM (Ki), D1 receptor:83 nM (Ki), 5-HT2B receptor:27 nM (Ki), D3 receptor:0.71 nM (Ki) |
| In vitro | In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7)[1]. Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+?toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone[4]. . |
| Molecular Weight | 351.93 |
| Formula | C19H26ClNOS |
| Cas No. | 102120-99-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (142.07 mM) | |||||||||||||||||||||||||||||||||||
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