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(Rac)-Rotigotine hydrochloride
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Catalog No. T12676Cas No. 102120-99-0
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine, a full agonist of the dopamine receptor and a partial agonist of the 5-HT1A receptor.
(Rac)-Rotigotine hydrochloride
😃Good
Catalog No. T12676Cas No. 102120-99-0
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine, a full agonist of the dopamine receptor and a partial agonist of the 5-HT1A receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mL x 10 mM (in DMSO) | $52 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine, a full agonist of the dopamine receptor and a partial agonist of the 5-HT1A receptor. |
| Targets&IC50 | D2 receptor:13.5 nM (Ki), D5 receptor:5.4 nM (Ki), 5-HT1A receptor:30 nM (Ki), 5-HT2B receptor:27 nM (Ki), D3 receptor:0.71 nM (Ki), D4 receptor:3.9-15 nM (Ki), D1 receptor:83 nM (Ki) |
| In vitro | In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7)[1]. Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+?toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone[4]. . |
| Molecular Weight | 351.93 |
| Formula | C19H26ClNOS |
| Cas No. | 102120-99-0 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (142.07 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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