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α-Tocopherol phosphate disodium

Catalog No. T63918 CAS 60934-46-5

Synonyms: Vitamin E phosphate disodium, TocP disodium

α-Tocopherol phosphate (alpha-Tocopherol phosphate) is an antioxidant that scavenges UVA1-induced reactive oxygen species (ROS) and protects against long-wave UVA1-induced cell death. alpha-Tocopherol phosphate disodium impedes endothelial progenitor cell apoptosis, enhances endothelial progenitor cell migration under high glucose/low oxygen conditions and promotes angiogenesis. α-Tocopherol phosphate disodium prevents apoptosis, enhances migration of endothelial progenitor cells under high glucose/low oxygen conditions and promotes angiogenesis.

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α-Tocopherol phosphate disodium, CAS 60934-46-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Vitamin E phosphate disodium, TocP disodium
Molecular Weight	554.65
Formula	C29H49Na2O5P
CAS No.	60934-46-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 4.1 mg/mL (7.4 mM), ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Saleh MM, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11(1):22400. 2. Wu Z, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018 Apr;67(4):1263-1273.e1.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

α-Tocopherol phosphate disodium 60934-46-5 Apoptosis Immunology/Inflammation Metabolism NF-Κb oxidation-reduction Reactive Oxygen Species Antioxidant Vitamin E phosphate disodium TocP disodium Inhibitor inhibitor inhibit

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