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β-Nicotinamide mononucleotide

β-Nicotinamide mononucleotide
β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.
Catalog No. T4721Cas No. 1094-61-7
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Purity:100%
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β-Nicotinamide mononucleotide

Purity: 99.66%
Catalog No. T4721Alias β-NM, NMNCas No. 1094-61-7

β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.
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Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$46In Stock
25 mg$71In Stock
50 mg$108In Stock
100 mg$153In Stock
500 mg$377In Stock
1 g$558In Stock
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Product Introduction

Bioactivity
Description
β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.
In vitro
METHODS: Human corneal epithelial cells HCECs were treated with glucose (25 mM) and β-nicotinamide mononucleotide (5-1000 µM) for 48 h. Cell viability was measured by Trypan blue staining.
RESULTS: The effects of different concentrations of β-nicotinamide mononucleotide on HCEC damage induced by high glucose were analyzed. 125, 250 and 500 µM β-nicotinamide mononucleotide showed significant protective effects. [1]
METHODS: Late passaged MSCs LP MSCs were treated with β-nicotinamide mononucleotide (100 µM) for 24 h and mitochondrial morphology was analyzed.
RESULTS: The mitochondrial staining in LP-MSCs was more diffuse and less intense, while the distribution of mitochondria became concentrated after β-nicotinamide mononucleotide treatment. β-nicotinamide mononucleotide treatment could effectively normalize the mitochondrial morphology and improve the function of mitochondria in senescent MSCs. [2]
In vivo
METHODS: To study the effects on aging, β-nicotinamide mononucleotide (100-300 mg/kg) was administered in drinking water to normally aging wild-type C57BL/6N mice. The administration began at 5 months of age and continued for 12 months until the mice were 17 months old.
RESULTS: β-nicotinamide mononucleotide effectively attenuated age-related physiological decline in mice. β-nicotinamide mononucleotide did not have any significant toxic or deleterious effects, inhibited age-related weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and lipid levels, and improved insulin resistance. sensitivity and lipid levels, and improved eye function and other pathophysiology. [3]
Aliasβ-NM, NMN
Chemical Properties
Molecular Weight334.22
FormulaC11H15N2O8P
Cas No.1094-61-7
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: Insoluble
H2O: 50 mg/mL(149.60 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.9920 mL14.9602 mL29.9204 mL149.6021 mL
5 mM0.5984 mL2.9920 mL5.9841 mL29.9204 mL
10 mM0.2992 mL1.4960 mL2.9920 mL14.9602 mL
20 mM0.1496 mL0.7480 mL1.4960 mL7.4801 mL
50 mM0.0598 mL0.2992 mL0.5984 mL2.9920 mL
100 mM0.0299 mL0.1496 mL0.2992 mL1.4960 mL

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