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(4E)-SUN9221
(4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist, exhibiting antihypertensive and antiplatelet aggregation activities in hypertensive rats.
Catalog No. T12596Cas No. 222318-55-0
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Purity:97.79%
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(4E)-SUN9221
Catalog No. T12596Cas No. 222318-55-0
(4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist, exhibiting antihypertensive and antiplatelet aggregation activities in hypertensive rats.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $700 | In Stock | |
| 5 mg | $1,800 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | (4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist, exhibiting antihypertensive and antiplatelet aggregation activities in hypertensive rats. |
| Targets&IC50 | Platelet aggregation:14 nM, Collagen:10 nM, ADP:35 nM |
| In vitro | In human platelet-rich plasma (PRP), (4E)-SUN9221 potently inhibits collagen-, ADP-, and epinephrine-induced platelet aggregation, with IC50s of 10 nM, 35 nM, and 14 nM, respectively. Additionally, (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22)[1]. |
| In vivo | In conscious spontaneously hypertensive rats (SHR), (4E)-SUN9221 reduces blood pressure in a dose-dependent manner when administered orally at doses of 1, 3, and 10 mg/kg. Specifically, (4E)-SUN9221 at a dose of 3 mg/kg exhibits antihypertensive activity in SHR[1]. |
| Molecular Weight | 454.54 |
| Formula | C25H31FN4O3 |
| Cas No. | 222318-55-0 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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