10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.

7-Xylosyl-10-deacetyltaxol induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9[1].

7-Xylosyl-10-deacetyltaxol is an active compound used in traditional Chinese medicine to treat cancer.7-Xylosyl-10-deacetyltaxol through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 7-Xylosyl-10-deacetyltaxol transport (16.3?±?6.3?×?10 (-6)?cm/s; n?=?3) suggests that the drug may still be effectively absorbed in the intestinal tract[2].