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2BAct

Catalog No. T9149 CAS 2143542-28-1

Synonyms: 2B-Act, 2B Act

2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

2BAct, CAS 2143542-28-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 89.00
5 mg	In stock	$ 222.00
10 mg	In stock	$ 355.00
25 mg	In stock	$ 589.00
50 mg	In stock	$ 842.00
100 mg	In stock	$ 1,130.00
1 mL * 10 mM (in DMSO)	In stock	$ 259.00

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Purity: 97.97%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
Targets&IC50	eIF2B:33 nM (EC50)

Synonyms	2B-Act, 2B Act
Molecular Weight	440.8
Formula	C19H16ClF3N4O3
CAS No.	2143542-28-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 240 mg/mL (544.46 mM), Sonication is recommended.

References and Literature

1. Wong YL, LeBon L, Basso AM, Kohlhaas KL, Nikkel AL, Robb HM, Donnelly-Roberts DL, Prakash J, Swensen AM, Rubinstein ND, Krishnan S, McAllister FE, Haste NV, O'Brien JJ, Roy M, Ireland A, Frost JM, Shi L, Riedmaier S, Martin K, Dart MJ, Sidrauski C. eIF2B activator prevents neurological defects caused by a chronic integrated stress response. Elife. 2019 Jan 9;8. pii. e42940.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library NO PAINS Compound Library Orally Active Compound Library Endoplasmic Reticulum Stress Compound Library Bioactive Compounds Library Max Reprogramming Compound Library Bioactive Compound Library Apoptosis Compound Library

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Related compounds with same targets

AMC-01 ATPγS tetralithium salt SBI-0640756 Vaccarin GCN2-IN-6 MK-28 GP 1a Briciclib

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Molecular Weight Calculator

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Mass of a compound required to prepare a solution of known volume and concentration
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

2BAct 2143542-28-1 Apoptosis PERK permeable primary 2B-Act inhibit 2B Act Eukaryotic Initiation Factor (eIF) stress defects response fibroblast neurological Inhibitor CNS inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.