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5-Aminolevulinic acid hydrochloride

Catalog No. T1662 CAS 5451-09-2

Synonyms: Hydrangin, 5-ALA, 5-Aminolevulinic acid HCl, ALA hydrochloride

5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.

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5-Aminolevulinic acid hydrochloride Chemical Structure

5-Aminolevulinic acid hydrochloride, CAS 5451-09-2

Pack Size	Availability	Price/USD
50 mg	In stock	$ 33.00
100 mg	In stock	$ 46.00
200 mg	In stock	$ 48.00
1 g	In stock	$ 67.00
5 g	In stock	$ 179.00
10 g	In stock	$ 271.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.91%

Purity: 99.77%

Purity: 99.76%

Purity: 99.33%

Purity: 98.07%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.

In vitro

5-Aminolevulinic acid (5-ALA), a non-fluorescent prodrug, facilitates the intracellular build-up of fluorescent porphyrins in malignant gliomas, aiding in their intraoperative identification and removal. A study with a median follow-up of 35.4 months (95% CI 1.0-56.7) showed that 65% (90 out of 139) of patients treated with 5-ALA achieved complete resection of contrast-enhancing tumors, compared to only 36% (47 out of 131) in those using white light, marking a significant difference of 29% (95% CI 17-40, p<0.0001). Additionally, those treated with 5-ALA exhibited a higher 6-month progression-free survival rate of 41.0% (32.8-49.2) versus 21.1% (14.0-28.2) for the white light group, a difference of 19.9% (9.1-30.7, p=0.0003, Z test). However, 5-ALA alone was deemed insufficient for achieving gross total resection without risking postoperative neurological damage. In treating functional grade III gliomas, the combination of intraoperative MRI (iMRI) with functional neuronavigation significantly outperformed the 5-ALA resection technique.

Synonyms	Hydrangin, 5-ALA, 5-Aminolevulinic acid HCl, ALA hydrochloride
Molecular Weight	167.59
Formula	C5H10ClNO3
CAS No.	5451-09-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 31 mg/mL (185 mM)

Ethanol: 6 mg/mL (35.8 mM)

DMSO: 32 mg/mL (190.9 mM)

References and Literature

1. Karmakar S, et al. Neurosci Lett,2007, 415(3), 242-247. 2. Onuki J, et al. Arch Biochem Biophys,2004, 432(2), 178-187. 3. Emanuelli T, et al. Neurochem Int,2001, 38(3), 213-218. 4. Jan CR, et al. Biochim Biophys Acta,1999, 1448(3), 533-542. 5. Cheng J, et al. Int J Nanomedicine,2013, 8, 669-676.

Citations

1. Wang L, Qi C, Cao H, et al.Engineered Cytokine‐Primed Extracellular Vesicles with High PD‐L1 Expression Ameliorate Type 1 Diabetes.Small.2023: 2301019.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Traditional Chinese Medicine Monomer Library Drug Repurposing Compound Library Anti-Cancer Drug Library EMA Approved Drug Library Human Endogenous Metabolite Library Anti-Tumor Natural Product Library RO5 Drug-like Natural Product Library

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Keywords

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