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5-HT7R antagonist 3
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Catalog No. T201849Cas No. 1887043-58-4
Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.
5-HT7R antagonist 3
😃Good
Catalog No. T201849Cas No. 1887043-58-4
Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities. |
| Targets&IC50 | 5-HT1A Receptor:8930nM(ki), D2 Receptor:511nM(ki), 5-HT7 Receptor:8nM(ki), 5-HT2A Receptor:5786nM(ki) |
| In vitro | 5-HT 7 R antagonist 3, active across a range of 1 pM to 1 μM, inhibits cAMP production in cells stably expressing human 5-HT, achieving an IC50 of 113 nM and a K_b of 14 nM. |
| In vivo | The compound 5-HT7R antagonist 3, administered intraperitoneally at doses of 1.25-10 mg/kg to male BalbC mice (20-25 g) 60 minutes before testing, exhibited significant anti-anxiety and antidepressant effects. |
| Molecular Weight | 516.61 |
| Formula | C30H33FN4O3 |
| Cas No. | 1887043-58-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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