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6-Hydroxy-DOPA

Catalog No. T26396 CAS 21373-30-8

Synonyms: 6-Hydroxy-DL-DOPA

6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.

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6-Hydroxy-DOPA, CAS 21373-30-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 71.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 417.00
50 mg	In stock	$ 619.00
100 mg	In stock	$ 879.00
500 mg	In stock	$ 1,790.00
1 mL * 10 mM (in DMSO)	In stock	$ 116.00

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Purity: 97.23%

Purity: 96.59%

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Description	6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
In vitro	We identify the small molecule 6-hydroxy-DL-dopa (6-OH-dopa) as a major allosteric inhibitor of the RAD52 ssDNA binding domain. For example, we find that multiple small molecules bind to and completely transform RAD52 undecamer rings into dimers, which abolishes the ssDNA binding channel observed in crystal structures. 6-OH-Dopa also disrupts RAD52 heptamer and undecamer ring superstructures, and suppresses RAD52 recruitment and recombination activity in cells with negligible effects on other double-strand break repair pathways.
In vivo	Importantly, we show that 6-OH-dopa selectively inhibits the proliferation of BRCA-deficient cancer cells, including those obtained from leukemia patients. Taken together, these data demonstrate small-molecule disruption of RAD52 rings as a promising mechanism for precision medicine in BRCA-deficient cancers.

Synonyms	6-Hydroxy-DL-DOPA
Molecular Weight	213.19
Formula	C9H11NO5
CAS No.	21373-30-8

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.13 mg/mL (10 mM)

References and Literature

1. Chandramouly G, McDevitt S, Sullivan K, Kent T, Luz A, Glickman JF, Andrake M, Skorski T, Pomerantz RT. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015 Nov 19;22(11):1491-1504. doi: 10.1016/j.chembiol.2015.10.003. Epub 2015 Nov 5. PubMed PMID: 26548611; PubMed Central PMCID: PMC4701204. 2. Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM 3rd. Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One. 2009 Jun 1;4(6):e5740. doi: 10.1371/journal.pone.0005740. PubMed PMID: 19484131; PubMed Central PMCID: PMC2685009.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library Bioactive Compound Library Anti-Cancer Compound Library

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Keywords

6-Hydroxy-DOPA 21373-30-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis U20S effective ssDNA 6 Hydroxy DOPA 6HydroxyDOPA Inhibitor allosteric 6-Hydroxy-DL-DOPA inhibit selective HCC1937 cancer inhibitor

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