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740 Y-P

Catalog No. TQ0003   CAS 1236188-16-1
Synonyms: 740YPDGFR, PDGFR 740Y-P

740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
740 Y-P Chemical Structure
740 Y-P, CAS 1236188-16-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 89.00
5 mg In stock $ 265.00
10 mg In stock $ 393.00
25 mg In stock $ 619.00
50 mg 5 days $ 877.00
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Purity: 99.87%
Purity: 98.3%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.
In vitro 740 Y-P is a synthetic biotinylated peptide. 740 Y-P stimulates mitogenesis at the lowest concentration tested (1 mg/mL). The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%) and in the former instance, a maximal response observed at 50 mg/mL. 740Y-P peptide to stimulate mitogenesis is highly specific and not a general feature of a cell-permeable SH2 domain-binding peptide [1]. 740Y-P is as effective as a growth factor (FGF2) at promoting neuronal cell survival via the established PI 3-kinase-Akt survival cascade. Stimulation of neuronal cell survival by the PDGFR740Y-P peptide is dose-dependent and does not require insulin[2].
Synonyms 740YPDGFR, PDGFR 740Y-P
Molecular Weight 3270.7
Formula C141H222N43O39PS3
CAS No. 1236188-16-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 15 mg/mL (4.58 mM)

TargetMolReferences and Literature

1. Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52. 2. Williams EJ, Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol Cell Neurosci. 1999 Apr;13(4):272-80. 3. Zhao Y, Guo W, Gu X, et al. Repression of deoxynivalenol-triggered cytotoxicity and apoptosis by mannan/β-glucans from yeast cell wall: Involvement of autophagy and PI3K-AKT-mTOR signaling pathway[J]. International Journal of Biological Macromolecules. 2020, 164: 1413-1421.

TargetMolCitations

1. Zuo X, Wei X, Ju C, et al. Protective Effect of Photobiomodulation against Hydrogen Peroxide-Induced Oxidative Damage by Promoting Autophagy through Inhibition of PI3K/AKT/mTOR Pathway in MC3T3-E1 Cells. Oxidative Medicine and Cellular Longevity. 2022 2. Rao Z, Li X, Zhang X, et al. Fengreqing Oral Liquid Exerts Anti-Inflammatory Effects by Promoting Apoptosis and Inhibiting PI3K/AKT and NF-κB Signaling Pathways. Frontiers in Pharmacology. 2022, 13: 824579-824579 3. Mai L, He G, Chen J, et al. Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells. Stem Cells International. 2021, 2021. 4. Zhao Y, Guo W, Gu X, et al. Repression of deoxynivalenol-triggered cytotoxicity and apoptosis by mannan/β-glucans from yeast cell wall: Involvement of autophagy and PI3K-AKT-mTOR signaling pathway. International Journal of Biological Macromolecules. 2020, 164: 1413-1421 5. Deng X, Liu X, Hu B, et al.Upregulation of MTHFD2 is associated with PD‑L1 activation in bladder cancer via the PI3K/AKT pathway.International Journal of Molecular Medicine.2023, 51(2): 1-15. 6. Guo A, Lin J, Zhong P, et al.Phellopterin attenuates ovarian cancer proliferation and chemoresistance by inhibiting the PU. 1/CLEC5A/PI3K-AKT feedback loop.Toxicology and Applied Pharmacology.2023: 116691.

Related compound libraries

This product is contained In the following compound libraries:
PI3K-AKT-mTOR Compound Library Oxidation-Reduction Compound Library Neural Regeneration Compound Library

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Keywords

740 Y-P 1236188-16-1 Autophagy PI3K/Akt/mTOR signaling PI3K VSMC inhibit alzheimer’s disease aortic p85 binding SH2 740YPDGFR 740 Y P cancer 740 YP PDGFR 740Y-P peptide Inhibitor thoracic Phosphoinositide 3-kinase inhibitor

 

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