store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 89.00 | |
5 mg | In stock | $ 265.00 | |
10 mg | In stock | $ 393.00 | |
25 mg | In stock | $ 619.00 | |
50 mg | 5 days | $ 877.00 |
Description | 740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K. |
In vitro | 740 Y-P is a synthetic biotinylated peptide. 740 Y-P stimulates mitogenesis at the lowest concentration tested (1 mg/mL). The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%) and in the former instance, a maximal response observed at 50 mg/mL. 740Y-P peptide to stimulate mitogenesis is highly specific and not a general feature of a cell-permeable SH2 domain-binding peptide [1]. 740Y-P is as effective as a growth factor (FGF2) at promoting neuronal cell survival via the established PI 3-kinase-Akt survival cascade. Stimulation of neuronal cell survival by the PDGFR740Y-P peptide is dose-dependent and does not require insulin[2]. |
Synonyms | 740YPDGFR, PDGFR 740Y-P |
Molecular Weight | 3270.7 |
Formula | C141H222N43O39PS3 |
CAS No. | 1236188-16-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 15 mg/mL (4.58 mM)
You can also refer to dose conversion for different animals. More
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740 Y-P 1236188-16-1 Autophagy PI3K/Akt/mTOR signaling PI3K VSMC inhibit alzheimer’s disease aortic p85 binding SH2 740YPDGFR 740 Y P cancer 740 YP PDGFR 740Y-P peptide Inhibitor thoracic Phosphoinositide 3-kinase inhibitor