Powder: -20°C for 3 years | In solvent: -80°C for 1 year
8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg/ L against B. xylophilus and is 117.5 mg/L against P. redivivus.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 156.00 | |
5 mg | In stock | $ 333.00 | |
10 mg | In stock | $ 568.00 | |
25 mg | In stock | $ 897.00 | |
50 mg | In stock | $ 1,180.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 371.00 |
Description | 8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg/ L against B. xylophilus and is 117.5 mg/L against P. redivivus. |
Targets&IC50 | P450 3A4:3.93 μM (IC50) |
In vitro | Through bioassay-guided fractionations, three coumarins were obtained from the extract of H. candicans and determined to be 8-Geranyloxypsoralen (1), imperatorin (2), and heraclenin (3) based on spectra data. All three compounds possessed nematicidal activities against the two tested nematodes. The median lethal concentrations (LC(50)) of compounds 1-3 at 72 h were 188.3, 161.7, and 114.7 mg L(-1) respectively against B. xylophilus and were 117.5, 179.0, and 148.7 mg L(-1) respectively against P. redivivus[1] |
Source |
Molecular Weight | 338.4 |
Formula | C21H22O4 |
CAS No. | 7437-55-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (132.98 mM)
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8-Geranyloxypsoralen 7437-55-0 Metabolism Microbiology/Virology Neuroscience BACE P450 Anti-infection CYPs Cytochrome P450 8Geranyloxypsoralen inhibit Inhibitor 8 Geranyloxypsoralen inhibitor